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PhD + post-doc offer INRA/INRIA (closed)

Function of the post-transcriptional regulatory system CSR in the dynamic of the metabolic adaption in the model bacterium Escherichia coli.


The bacterium Escherichia coli is the most common facultative aerobe in the gut. Its strains diverge in their capacity to colonize and the nature of their relationship to the host (commensalism or virulence). In this ever-changing and competitive environment, the capacity to switch from one nutritional source to another is a key for an efficient colonization. Personal data and published results suggested that the post-transcriptional regulatory system CSR is a major coordinator of these metabolic transitions.

The PhD student will have to unravel this function (i) by producing relevant experimental data during a defined transition (transcriptome, stabilome and metabolome) and (ii) by integrating these results into a mathematic model describing the fine tuning of the transition.

The position will be based at the Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés in Toulouse. Regular visits to the Ibis team at INRIA Grenoble - Rhône-Alpes are planned for the modeling aspects of the project.

Skills and Profile

The profile is open, with a preference for candidates with a background in biology and a strong interest for systems biology. Knowledge on metabolism and -omics approaches is a plus.

Propensity to interdisciplinary research, strong motivation, ability to work in group are necessary and expected.

Application and additional information

The Young Scientist Contract is a fixed-term public law contract. Its initial duration is three years. Two extra periods of three months maximum may be granted exceptionally in order to finish the thesis.

Once the young scientist has successfully obtained his/her thesis, the contract can be renewed for a duration of 2 years on condition that he/she spends time abroad.

Young scientist contracts have attractive remuneration conditions. Before obtaining his/her PhD, the doctoral student receives 2167€ (gross) per month. After obtaining his/her PhD, the remuneration is 2398€ (gross) per month.

Interested candidates should contact :


Delphine ROPERS (INRIA, Grenoble)

Brice ENJALBERT (LISBP, Toulouse)