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Dealing with discontinuities in the qualitative simulation of genetic regulatory networks

H. de Jong, J.-L. Gouzé, C. Hernandez, M. Page, T. Sari, J. Geiselmann

Proceedings of 15th European Conference on Artifical Intelligence, ECAI 2002, pp. 412-416, IOS Press, Amsterdam, 2002

Methods developed for the qualitative simulation of dynamical systems have turned out to be powerful tools for studying genetic regulatory networks. We present a generalization of a simulation method based on piecewise-linear differential equation models that is able to deal with discontinuities. The method is sound and has been implemented in a computer tool called GNA.