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Qualitative simulation of genetic regulatory networks : Method and application.

H. de Jong, M. Page, C. Hernandez, J. Geiselmann.

Proceedings of the Seventeenth International Joint Conference on Artificial Intelligence, IJCAI-01, B. Nebel (ed.), Morgan Kaufmann, San Mateo, CA, 67-73, 2001

Computer modeling and simulation are indispensable for understanding the functioning of an organism on a molecular level. We present an implemented method for the qualitative simulation of large and complex genetic regulatory networks. The method allows a broad range of regulatory interactions between genes to be represented and has been applied to the analysis of a real network of biological interest, the network controlling the inititation of sporulation in the bacterium B. subtilis.