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François Lemaire - Applying a rigorous quasi-steady state approximation method for proving the absence of oscillations in models of genetic circuits

Seminar at INRIA Grenoble - Rhône-Alpes, Montbonnot, January 21, 2009, 11 AM


Abstract

In this talk, a rigorous quasi-steady state approximation method is applied in order to study the absence of oscillations in a family of models describing a gene regulated by a polymer of its own protein. A result presented in a former paper at "Algebraic Biology 2007" is thereby generalized.

The talk presents different methods recently developed in the Computer Algebra team of Lille like : model reduction and model reparametrization. Those methods are based on differential algebra and Lie symmetries.

The talk will be followed by a demo of the MABSys maple package.

Réferences :
-  http://hal.archives-ouvertes.fr/hal-00307915/fr/
-  http://hal.archives-ouvertes.fr/hal-00184558/fr/

Speaker

François Lemaire, Laboratoire d’Informatique Fondamentale de Lille, Université de Lille I

Venue

INRIA Grenoble - Rhône-Alpes, Montbonnot, January 21, 2009, 11 AM, room A104